In the Noether, first time ever playing it, I got hit with legitimate RNG screw. One of the few times I can't imagine what else I could have done.
I was working my way to activate the shields, and it was going fine. I had somewhere between 50 and 60 scrap, and had completed two perfect battles already. I'd already done Manpower on Zoltan A, a run that carried to sector 7 on normal, so I'd learned Zoltan power management and Zoltan Shield use. I had ~12 wins on normal at that point and know most of the tips and strategies.
Anyway, I jump to my sixth beacon to find myself in an asteroid field. So I say, well shit, this is what happens if you don't have long range scanners. I check the enemy weaponry, and see a Burst Laser Mk. II and an Ion Stunner. I plan to run, but fight in the meantime. I had full health, so I wasn't terribly worried. I just needed to kill the enemy quick so the FTL would spin up faster. So I charge up my ions and manage to fire them off. They both hit, and I get a nice pike beam across five rooms. But the enemy had 3 weapon power, and still has his lasers up. Then the zoltan shield goes down, and I have a 10 second wait minimum to fire again, and god only knows how long before the engines rev.
Almost immediately, an asteroid hits my engines. I'm not totally screwed yet, I might still escape with 5-10 health if I'm lucky. So, of course, both lasers hit my engines, lighting a fire I try to vent, as my barely alive engineer rushes to the medbay. Then another asteroid flies in and hits my doors, breaching them. And yet another hits my piloting. And, as it is an asteroid field, they keep bombarding me and open two more breaches between the engines and the medbay. Amazingly, O2 and medbay are still up.
The other ship breaks apart in the asteroids, but I know I'm almost entirely screwed. From asteroids I no longer have engines or piloting or doors and there are three breaches between medbay and engines. There's enough vented space to kill my zoltan unless they progress one breach at a time. And the asteroids just keep flying in. I start on the breaches, and another asteroid hits and kills two of the zoltan as they run back to the medbay. At that point I keep fighting, but O2 goes out and the final zoltan quickly suffocates.
Hit a strong offensive in an asteroid field in the Noether before shields. Engines went down first, then piloting, then doors, then O2, with 3 breaches between medbay and engines. Then everyone died.